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EMMAA Dashboard Queries

Test: "EGF leads to the phosphorylation of MAPK1." for MARM_MODEL (PySB) on 2020-02-12

Path Support
EGF ↔ EGFR ↔ EGFR ↔ GRB2 ↔ GRB2 → KRAS ↔ KRAS ↔ BRAF → MAP2K1 → MAPK1 EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR binds EGFR bound to EGF.
EGFR ↔ GRB2
EGFR bound to EGFR binds GRB2.
SOS1 ↔ GRB2
SOS1 binds active GRB2.
SOS1 → KRAS
SOS1 bound to GRB2 activates KRAS.
BRAF ↔ KRAS
BRAF binds active KRAS.
BRAF ↔ BRAF
BRAF binds BRAF bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1.
MAP2K1 → MAPK1
Phosphorylated MAP2K1 phosphorylates MAPK1.