IndraLab

EMMAA Dashboard Queries

Test: " EGF leads to the phosphorylation of MAPK1." for MARM_MODEL (PySB)

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EGF ↔ EGFR ↔ EGFR ↔ GRB2 ↔ GRB2 → KRAS ↔ RAF1 ↔ RAF1 → MAP2K1 → MAPK1 EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR binds EGFR bound to EGF.
EGFR ↔ GRB2
EGFR bound to EGFR binds GRB2.
SOS1 ↔ GRB2
SOS1 binds active GRB2.
SOS1 → KRAS
SOS1 bound to GRB2 activates KRAS.
KRAS ↔ RAF1
Active KRAS binds RAF1.
BRAF ↔ RAF1
BRAF binds RAF1 bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1.
MAP2K1 → MAPK1
Phosphorylated MAP2K1 phosphorylates MAPK1.