IndraLab

EMMAA Dashboard Queries

Test: " Phosphatase-active DUSP6 inhibits MAP2K1." for MARM_MODEL (Unsigned Graph)

Path Support
DUSP6 → MAPK1 → EGFR ↔ GRB2 ↔ GRB2 → KRAS ↔ KRAS → MAP2K1 DUSP6 → MAPK1
DUSP6 dephosphorylates MAPK1.
MAPK1 → EGFR
MAPK1 increases the amount of EGFR.
EGFR ↔ GRB2
GRB2 binds EGFR.
EGFR binds GRB2.
SOS1 ↔ GRB2
SOS1 binds GRB2.
GRB2 binds SOS1.
SOS1 → KRAS
SOS1 activates KRAS.
BRAF ↔ KRAS
KRAS binds BRAF.
BRAF binds KRAS.
BRAF → MAP2K1
BRAF phosphorylates MAP2K1.