|EGF → EGF → EGFR → EGFR → GRB2 → KRAS → KRAS → RAF1 → MAP2K1 → MAPK1 → DUSP6 → MAPK1 → EGFR||
EGF → EGF
EGF is a part of EGF bound to EGFR.
EGF → EGFR
EGF bound to EGFR has a component EGFR.
EGFR → EGFR
EGFR is a part of EGFR bound to GRB2.
GRB2 bound to EGFR is active.
GRB2 → GRB2
GRB2 is a part of GRB2 bound to SOS1.
SOS1 → KRAS
SOS1 bound to GRB2 activates KRAS.
KRAS → KRAS
KRAS is a part of KRAS bound to RAF1.
KRAS → RAF1
KRAS bound to RAF1 has a component RAF1.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1.
MAP2K1 → MAPK1
Phosphorylated MAP2K1 phosphorylates MAPK1.
MAPK1 → DUSP6
Phosphorylated MAPK1 increases the amount of DUSP6.
DUSP6 → MAPK1
DUSP6 dephosphorylates MAPK1.
MAPK1 → EGFR
Phosphorylated MAPK1 increases the amount of EGFR.