IndraLab

EMMAA Dashboard Queries

Test: "EGFR activates AKT1." for RASMODEL (PyBEL) on 2020-02-12

Path Support
EGFR → EGFR → SOS1 → IRS1 → IRS1 → IRS1 → PIK3CA → phosphatidylinositol trisphosphate → phosphatidylinositol trisphosphate → AKT1 EGFR → EGFR
EGFR phosphorylated on Y1110 is a part of EGFR bound to SOS1 and phosphorylated on Y1110.
EGFR → SOS1
EGFR bound to SOS1 and phosphorylated on Y1110 has a component SOS1.
SOS1 → IRS1
SOS1 is a part of tyrosine-phosphorylated IRS1 bound to SOS1.
IRS1 → IRS1
Tyrosine-phosphorylated IRS1 bound to SOS1 has a component tyrosine-phosphorylated IRS1.
IRS1 → IRS1
Tyrosine-phosphorylated IRS1 is a part of tyrosine-phosphorylated IRS1 bound to PIK3CA.
IRS1 → PIK3CA
Tyrosine-phosphorylated IRS1 bound to PIK3CA has a component PIK3CA.
PIK3CA → phosphatidylinositol trisphosphate
Active PIK3CA increases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate → phosphatidylinositol trisphosphate
Phosphatidylinositol trisphosphate is a part of phosphatidylinositol trisphosphate bound to AKT1.
phosphatidylinositol trisphosphate → AKT1
Phosphatidylinositol trisphosphate bound to AKT1 has a component AKT1.