|BRAF → MAP2K1 → MAPK1 → ELK1||
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S222.
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.
MAPK1 phosphorylated on T185 and Y187 is active.
MAPK1 → ELK1
Active MAPK1 phosphorylates ELK1 on S383.
ELK1 phosphorylated on S383 and S389 is active.