IndraLab

EMMAA Dashboard Queries

Test: "Phosphatase-active PTEN inhibits MTOR." for RASMODEL (PyBEL) on 2020-02-12

Path Support
PTEN ⊣ phosphatidylinositol trisphosphate → phosphatidylinositol trisphosphate → AKT1 → MTOR PTEN ⊣ phosphatidylinositol trisphosphate
PTEN decreases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate → phosphatidylinositol trisphosphate
Phosphatidylinositol trisphosphate is a part of phosphatidylinositol trisphosphate bound to AKT1.
phosphatidylinositol trisphosphate → AKT1
Phosphatidylinositol trisphosphate bound to AKT1 has a component AKT1.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR
MTOR bound to RPTOR and RICTOR and phosphorylated on S2448 is active.