IndraLab

EMMAA Dashboard Queries

Test: "TSC2 inhibits RPS6KB1." for RASMODEL (PyBEL) on 2020-02-12

Path Support
TSC2 ⊣ RHEB → MTOR → MTOR → RPS6KB1 TSC2 ⊣ RHEB
Active TSC2 inhibits RHEB.
RHEB → MTOR
RHEB is a part of MTOR bound to RHEB.
MTOR
MTOR bound to RHEB, RPTOR, and RICTOR is active.
MTOR → MTOR
MTOR is a part of MTOR bound to RPTOR.
MTOR → RPS6KB1
Active MTOR bound to RPTOR phosphorylates RPS6KB1 on T412.
RPS6KB1
RPS6KB1 phosphorylated on T412 is active.