|EGFR → EGFR → KRAS → KRAS → RAF1 → MAP2K1 → MAPK1||
EGFR → EGFR
EGFR is a part of EGFR bound to SOS1.
SOS1 bound to EGFR is active.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
KRAS → KRAS
KRAS is a part of KRAS bound to RAF1.
KRAS → RAF1
KRAS bound to RAF1 has a component RAF1.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S222.
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.
MAPK1 phosphorylated on T185 and Y187 is active.