|SRC → RAF1 → RAF1 → MAP2K1 → MAPK1 → ELK1 → FOS_family → FOS_family → CCND1||
SRC → RAF1
Active SRC phosphorylates RAF1 bound to KRAS.
KRAS → RAF1
KRAS bound to RAF1 has a component phosphorylated RAF1.
Phosphorylated RAF1 is active.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S222.
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.
MAPK1 phosphorylated on T185 and Y187 is active.
MAPK1 → ELK1
Active MAPK1 phosphorylates ELK1 on S383.
ELK1 phosphorylated on S383 and S389 is active.
ELK1 → FOS_family
Active ELK1 in the nucleus increases the amount of FOS_family.
FOS_family → FOS_family
FOS_family is a part of FOS_family bound to JUN_family.
FOS_family → CCND1
FOS_family bound to JUN_family increases the amount of CCND1.