|IGF1R → IRS1 → IRS1 → SOS1 → KRAS → KRAS → RAF1 → MAP2K1 → MAPK1 → ELK1||
IGF1R → IRS1
Active IGF1R phosphorylates IRS1 on tyrosine.
IRS1 → IRS1
Tyrosine-phosphorylated IRS1 is a part of tyrosine-phosphorylated IRS1 bound to SOS1.
IRS1 → SOS1
Tyrosine-phosphorylated IRS1 bound to SOS1 has a component SOS1.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
KRAS → KRAS
KRAS is a part of KRAS bound to RAF1.
KRAS → RAF1
KRAS bound to RAF1 has a component RAF1.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S222.
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.
MAPK1 phosphorylated on T185 and Y187 is active.
MAPK1 → ELK1
Active MAPK1 phosphorylates ELK1 on S383.
ELK1 phosphorylated on S383 and S389 is active.