|RAF1 → MAP2K1 → MAPK1 → ETS1||
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S222.
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.
MAPK1 phosphorylated on T185 and Y187 is active.
MAPK1 → ETS1
Active MAPK1 phosphorylates ETS1 on T38.
ETS1 phosphorylated on T38 is active.