|EGFR → EGFR → IRS1 → IRS1||
EGFR → EGFR
EGFR is a part of EGFR bound to SOS1.
SOS1 bound to EGFR is active.
SOS1 → IRS1
SOS1 is a part of IRS1 bound to SOS1.
IRS1 → IRS1
IRS1 bound to SOS1 has a component IRS1.