IndraLab

EMMAA Dashboard Queries

Test: "EGF activates RAC1." for RASMODEL (PyBEL) on 2020-02-12

Path Support
EGF → EGFR → EGFR → SRC → TIAM1 → RAC1 EGF → EGFR
EGF bound to EGFR has a component EGFR.
EGFR → EGFR
EGFR is a part of EGFR bound to EGFR.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC
SRC phosphorylated on Y419 is active.
SRC → TIAM1
Active SRC phosphorylates TIAM1.
TIAM1
Phosphorylated TIAM1 is active.
TIAM1 → RAC1
Active TIAM1 activates RAC1.