|EGFR ↔ EGFR → SRC → AKT1 → MTOR ⊣ PPP2CA → IRS1 IRS1||
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → AKT1
Active SRC phosphorylates AKT1 on Y315.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
IRS1 phosphorylated on S312 is degraded.