IndraLab

EMMAA Dashboard Queries

Test: "EGF leads to the phosphorylation of MAPK1." for RASMODEL (PyBEL)

Path Support
EGF ↔ EGFR ↔ EGFR → KRAS ↔ RAF1 ↔ RAF1 → MAP2K1 → MAPK1 EGF ↔ EGFR
EGF binds EGFR.
SOS1 ↔ EGFR
SOS1 binds EGFR phosphorylated on Y1110.
SOS1
SOS1 bound to EGFR is active.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
KRAS ↔ RAF1
Active KRAS binds RAF1.
KRAS ↔ RAF1
Active KRAS binds RAF1.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S218.
MAP2K1
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.