IndraLab

EMMAA Dashboard Queries

Test: "Phosphatase-active PTEN inhibits MTOR." for RASMODEL (PyBEL)

Path Support
PTEN ⊣ phosphatidylinositol trisphosphate ↔ AKT1 ↔ AKT1 → MTOR PTEN ⊣ phosphatidylinositol trisphosphate
PTEN decreases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR
MTOR bound to RPTOR and RICTOR and phosphorylated on S2448 is active.