|SRC → BRAF → MAP2K1 → MAPK1 → CCND1||
SRC → BRAF
Active SRC phosphorylates BRAF bound to KRAS.
Phosphorylated BRAF is active.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S218.
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on T185.
MAPK1 phosphorylated on T185 and Y187 is active.
MAPK1 → CCND1
Active MAPK1 phosphorylates CCND1 on T286.