|MTOR ⊣ PPP2CA → IRS1 ↔ IRS1 ↔ EGFR ↔ EGFR → SRC||
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
Tyrosine-phosphorylated IRS1 is active.
SOS1 ↔ IRS1
SOS1 binds tyrosine-phosphorylated IRS1.
SOS1 bound to IRS1 is active.
SOS1 bound to EGFR is active.
SOS1 ↔ EGFR
SOS1 binds EGFR phosphorylated on Y1110.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC phosphorylated on Y419 is active.