IndraLab

EMMAA Dashboard Queries
Path Support
RPS6KB1 → IRS1 IRS1 → phosphatidylinositol trisphosphate ⊣ phosphatidylinositol trisphosphate → AKT1 → MTOR → RPS6KB1 RPS6KB1 → IRS1
RPS6KB1 phosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.
PIK3CA → phosphatidylinositol trisphosphate
Active PIK3CA increases the amount of phosphatidylinositol trisphosphate.
PTEN ⊣ phosphatidylinositol trisphosphate
PTEN decreases the amount of phosphatidylinositol trisphosphate.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR → RPS6KB1
Active MTOR bound to RPTOR phosphorylates RPS6KB1 on T412.