IndraLab

EMMAA Dashboard Queries
Path Support
PTEN ⊣ phosphatidylinositol trisphosphate ↔ AKT1 → AKT1 → MTOR ⊣ PPP2CA → IRS1 PTEN ⊣ phosphatidylinositol trisphosphate
PTEN decreases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.