|EGF ↔ EGFR ↔ EGFR → SRC → AKT1 → MTOR → AKT1||
EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → AKT1
Active SRC phosphorylates AKT1 on Y315.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR → AKT1
Active MTOR bound to RICTOR phosphorylates AKT1 on S473.