IndraLab

EMMAA Dashboard Queries
Path Support
IRS1 ↔ PIK3CA → phosphatidylinositol trisphosphate ↔ AKT1 → AKT1 → MTOR → AKT1 IRS1 ↔ PIK3CA
Tyrosine-phosphorylated IRS1 binds PIK3CA.
PIK3CA → phosphatidylinositol trisphosphate
Active PIK3CA increases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR → AKT1
Active MTOR bound to RICTOR phosphorylates AKT1 on S473.