|EGF ↔ EGFR ↔ EGFR → SRC → RAF1 → MAP2K1 → MAPK1||
EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → RAF1
Active SRC phosphorylates RAF1 bound to KRAS.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S218.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on T185.