IndraLab

EMMAA Dashboard Queries
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EGF ↔ EGFR ↔ EGFR → SRC → AKT1 → MTOR ⊣ PPP2CA → IRS1 IRS1 EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → AKT1
Active SRC phosphorylates AKT1 on Y315.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.