IndraLab

EMMAA Dashboard Queries

Test: "Phosphatase-active PTEN inhibits MTOR." for RASMODEL (PySB)

Path Support
PTEN ⊣ phosphatidylinositol trisphosphate → AKT1 → MTOR PTEN ⊣ phosphatidylinositol trisphosphate
PTEN decreases the amount of phosphatidylinositol trisphosphate.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.