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Test: "Kinase-active AKT1 inhibits RAF1." for RASMODEL (PySB)

Path Support
AKT1 → MTOR ⊣ PPP2CA → IRS1 IRS1 → KRAS ↔ RAF1 → RAF1 AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
KRAS ↔ RAF1
Active KRAS binds RAF1.
SRC → RAF1
Active SRC phosphorylates RAF1 bound to KRAS.