IndraLab

EMMAA Dashboard Queries

Test: "Kinase-active IGF1R activates ELK1." for RASMODEL (PySB)

Path Support
IGF1R → IRS1 ↔ IRS1 → KRAS ↔ KRAS → BRAF → MAP2K1 → MAPK1 → ELK1 IGF1R → IRS1
Active IGF1R phosphorylates IRS1 on tyrosine.
SOS1 ↔ IRS1
SOS1 binds tyrosine-phosphorylated IRS1.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
BRAF ↔ KRAS
BRAF binds active KRAS.
SRC → BRAF
Active SRC phosphorylates BRAF bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S218.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on T185.
MAPK1 → ELK1
Active MAPK1 phosphorylates ELK1 on S383.