|EGF ↔ EGFR ↔ EGFR → SRC → AKT1 → TSC2 ↔ TSC2 TSC2||
EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → AKT1
Active SRC phosphorylates AKT1 on Y315.
AKT1 → TSC2
Active AKT1 phosphorylates TSC2 on S939.
TSC1 ↔ TSC2
TSC1 binds TSC2 phosphorylated on S1798, S939, and T1462.
TSC2 not bound to TSC1 is degraded.