|EGF ↔ EGFR ↔ EGFR → SRC → BRAF → MAP2K1 → MAPK1 → ELK1 → FOS_family ↔ JUN_family → CCND1 ↔ CDK4 → RB1||
EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → BRAF
Active SRC phosphorylates BRAF bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S218.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on T185.
MAPK1 → ELK1
Active MAPK1 phosphorylates ELK1 on S383.
ELK1 → FOS_family
Active ELK1 in the nucleus increases the amount of FOS_family.
FOS_family ↔ JUN_family
FOS_family binds JUN_family.
FOS_family → CCND1
FOS_family bound to JUN_family increases the amount of CCND1.
CCND1 ↔ CDK4
CCND1 binds CDK4.
CDK4 → RB1
CDK4 bound to CCND1 phosphorylates RB1 on S807.