IndraLab

EMMAA Dashboard Queries
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PTEN ⊣ phosphatidylinositol trisphosphate → AKT1 → MTOR ⊣ PPP2CA → IRS1 IRS1 → KRAS ↔ KRAS → BRAF → MAP2K1 → MAPK1 PTEN ⊣ phosphatidylinositol trisphosphate
PTEN decreases the amount of phosphatidylinositol trisphosphate.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
BRAF ↔ KRAS
BRAF binds active KRAS.
SRC → BRAF
Active SRC phosphorylates BRAF bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S218.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.