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MTOR ⊣ PPP2CA → IRS1 IRS1 ↔ IRS1 → KRAS ↔ KRAS → BRAF → MAP2K1 → MAPK1 → ELK1 → FOS_family ↔ JUN_family → CCND1 MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.
SOS1 ↔ IRS1
SOS1 binds tyrosine-phosphorylated IRS1.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
BRAF ↔ KRAS
BRAF binds active KRAS.
SRC → BRAF
Active SRC phosphorylates BRAF bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S218.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on T185.
MAPK1 → ELK1
Active MAPK1 phosphorylates ELK1 on S383.
ELK1 → FOS_family
Active ELK1 in the nucleus increases the amount of FOS_family.
FOS_family ↔ JUN_family
FOS_family binds JUN_family.
FOS_family → CCND1
FOS_family bound to JUN_family increases the amount of CCND1.