IndraLab

EMMAA Dashboard Queries

Test: "Catalytically active AKT1S1 activates IRS1." for RASMODEL (PySB)

Path Support
AKT1S1 ↔ MTOR ⊣ PPP2CA → IRS1 IRS1 AKT1S1 ↔ MTOR
AKT1S1 not bound to p14_3_3 binds MTOR.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.