IndraLab

EMMAA Dashboard Queries

Test: "TSC1 bound to TSC2 inhibits MTOR." for RASMODEL (PySB)

Path Support
TSC1 ↔ TSC2 ⊣ RHEB ↔ MTOR ⊣ PPP2CA → IRS1 IRS1 → phosphatidylinositol trisphosphate ↔ AKT1 → AKT1 → MTOR TSC1 ↔ TSC2
TSC1 binds TSC2 phosphorylated on S1798, S939, and T1462.
TSC2 ⊣ RHEB
Active TSC2 inhibits RHEB.
RHEB ↔ MTOR
Active RHEB binds MTOR.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.
PIK3CA → phosphatidylinositol trisphosphate
Active PIK3CA increases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.