IndraLab

EMMAA Dashboard Queries

Test: "Kinase-active AKT1 activates GSK3A." for RASMODEL (PySB)

Path Support
phosphatidylinositol trisphosphate ↔ AKT1 → AKT1 → GSK3A phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.
AKT1 → GSK3A
Active AKT1 phosphorylates GSK3A on S21.