|EGF ↔ EGFR ↔ EGFR → SRC → AKT1 → MTOR → RPS6KB1 → RPS6||
EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → AKT1
Active SRC phosphorylates AKT1 on Y315.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR → RPS6KB1
Active MTOR bound to RPTOR phosphorylates RPS6KB1 on T412.
RPS6KB1 → RPS6
Active RPS6KB1 phosphorylates RPS6 on S235.