IndraLab

EMMAA Dashboard Queries

Test: "EGF activates RAC1." for RASMODEL (PySB)

Path Support
EGF ↔ EGFR ↔ EGFR → SRC → TIAM1 → RAC1 EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → TIAM1
Active SRC phosphorylates TIAM1.
TIAM1 → RAC1
Active TIAM1 activates RAC1.