|EGF ↔ EGFR ↔ EGFR → SRC → TIAM1 → RAC1
EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → TIAM1
Active SRC phosphorylates TIAM1.
TIAM1 → RAC1
Active TIAM1 activates RAC1.