IndraLab

EMMAA Dashboard Queries

Test: "TSC2 activates MAPK1." for RASMODEL (PySB)

Path Support
TSC2 ⊣ RHEB ↔ MTOR ⊣ PPP2CA → IRS1 IRS1 → KRAS ↔ KRAS → BRAF → MAP2K1 → MAPK1 TSC2 ⊣ RHEB
Active TSC2 inhibits RHEB.
RHEB ↔ MTOR
Active RHEB binds MTOR.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
BRAF ↔ KRAS
BRAF binds active KRAS.
SRC → BRAF
Active SRC phosphorylates BRAF bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S218.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on T185.