IndraLab

EMMAA Dashboard Queries

Test: "SOS1 activates MAPK1." for RASMODEL (PySB)

Path Support
SOS1 → KRAS ↔ KRAS → BRAF → MAP2K1 → MAPK1 SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
BRAF ↔ KRAS
BRAF binds active KRAS.
SRC → BRAF
Active SRC phosphorylates BRAF bound to KRAS.
BRAF → MAP2K1
Active BRAF phosphorylates MAP2K1 on S218.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on T185.