IndraLab

EMMAA Dashboard Queries

Test: "EGF activates AKT1." for RASMODEL (PySB)

Path Support
EGF ↔ EGFR ↔ EGFR → SRC → AKT1 → MTOR ⊣ PPP2CA → IRS1 IRS1 → phosphatidylinositol trisphosphate ↔ AKT1 → AKT1 EGF ↔ EGFR
EGF binds EGFR.
EGFR ↔ EGFR
EGFR bound to EGF binds EGFR bound to EGF.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC → AKT1
Active SRC phosphorylates AKT1 on Y315.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR ⊣ PPP2CA
Active MTOR inhibits PPP2CA.
PPP2CA → IRS1
Active PPP2CA dephosphorylates IRS1 on S312.
⊣ IRS1
IRS1 phosphorylated on S312 is degraded.
PIK3CA → phosphatidylinositol trisphosphate
Active PIK3CA increases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
PDPK1 → AKT1
Active PDPK1 phosphorylates AKT1 bound to phosphatidylinositol trisphosphate on T308.