IndraLab

EMMAA Dashboard Queries
Path Support
PTEN ⊣ phosphatidylinositol trisphosphate ↔ AKT1 → MTOR ⊣ PPP2CA → IRS1 ↔ IRS1 → KRAS ↔ KRAS → MAP2K1 → MAPK1 PTEN ⊣ phosphatidylinositol trisphosphate
PTEN decreases the amount of phosphatidylinositol trisphosphate.
phosphatidylinositol trisphosphate ↔ AKT1
Phosphatidylinositol trisphosphate binds AKT1.
AKT1 binds phosphatidylinositol trisphosphate.
AKT1 → MTOR
AKT1 phosphorylates MTOR.
MTOR ⊣ PPP2CA
MTOR inhibits PPP2CA.
PPP2CA → IRS1
PPP2CA dephosphorylates IRS1.
SOS1 ↔ IRS1
SOS1 binds IRS1.
IRS1 binds SOS1.
SOS1 → KRAS
SOS1 activates KRAS.
BRAF ↔ KRAS
KRAS binds BRAF.
BRAF binds KRAS.
BRAF → MAP2K1
BRAF phosphorylates MAP2K1.
MAP2K1 → MAPK1
MAP2K1 phosphorylates MAPK1.