IndraLab

EMMAA Dashboard Queries

Test: "Kinase-active MTOR increases the amount of CCND1." for RASMODEL (Unsigned Graph)

Path Support
MTOR ⊣ PPP2CA → IRS1 ↔ IRS1 → KRAS ↔ KRAS → MAP2K1 → MAPK1 → CCND1 MTOR ⊣ PPP2CA
MTOR inhibits PPP2CA.
PPP2CA → IRS1
PPP2CA dephosphorylates IRS1.
SOS1 ↔ IRS1
SOS1 binds IRS1.
IRS1 binds SOS1.
SOS1 → KRAS
SOS1 activates KRAS.
BRAF ↔ KRAS
KRAS binds BRAF.
BRAF binds KRAS.
BRAF → MAP2K1
BRAF phosphorylates MAP2K1.
MAP2K1 → MAPK1
MAP2K1 phosphorylates MAPK1.
MAPK1 → CCND1
MAPK1 phosphorylates CCND1.