IndraLab

EMMAA Dashboard Queries

Test: "EGF leads to the phosphorylation of AKT1 on S473." for RASMODEL (PyBEL) on 2020-02-12

Path Support
EGF → EGFR → EGFR → SRC → AKT1 → MTOR → MTOR → AKT1 EGF → EGFR
EGF bound to EGFR has a component EGFR.
EGFR → EGFR
EGFR is a part of EGFR bound to EGFR.
EGFR → SRC
EGFR bound to EGFR phosphorylates SRC on Y419.
SRC
SRC phosphorylated on Y419 is active.
SRC → AKT1
Active SRC phosphorylates AKT1 on Y315.
AKT1
AKT1 phosphorylated on Y315 is active.
AKT1 → MTOR
Active AKT1 phosphorylates MTOR on S2448.
MTOR
MTOR bound to RPTOR and RICTOR and phosphorylated on S2448 is active.
MTOR → MTOR
MTOR is a part of MTOR bound to RICTOR.
MTOR → AKT1
Active MTOR bound to RICTOR phosphorylates AKT1 on S473.