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Test: "SRC increases the amount of EGFR." for RASMODEL (PyBEL) on 2020-02-12

Path Support
SRC → RAF1 → RAF1 → MAP2K1 → MAPK1 → SOS1 → EGFR → EGFR → EGFR SRC
SRC phosphorylated on Y419 is active.
SRC → RAF1
Active SRC phosphorylates RAF1 bound to KRAS.
KRAS → RAF1
KRAS bound to RAF1 has a component phosphorylated RAF1.
RAF1
Phosphorylated RAF1 is active.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S222.
MAP2K1
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.
MAPK1
MAPK1 phosphorylated on T185 and Y187 is active.
MAPK1 → SOS1
Active MAPK1 phosphorylates SOS1 on S1178.
SOS1
SOS1 phosphorylated on S1178 is active.
SOS1 → EGFR
SOS1 is a part of EGFR bound to SOS1.
EGFR → EGFR
EGFR bound to SOS1 has a component EGFR.
EGFR → EGFR
EGFR is a part of EGFR bound to EGFR.
EGFR
EGFR bound to EGFR phosphorylates itself on Y1069.