|EGF → EGFR → EGFR → KRAS → KRAS → RAF1 → MAP2K1 → MAPK1 → ELK1 → FOS_family → FOS_family → CCND1 → CCND1 → RB1||
EGF → EGFR
EGF bound to EGFR has a component EGFR.
EGFR → EGFR
EGFR is a part of EGFR bound to SOS1.
SOS1 bound to EGFR is active.
SOS1 → KRAS
Active SOS1 activates KRAS in the membrane.
KRAS → KRAS
KRAS is a part of KRAS bound to RAF1.
KRAS → RAF1
KRAS bound to RAF1 has a component RAF1.
RAF1 → MAP2K1
Active RAF1 phosphorylates MAP2K1 on S222.
MAP2K1 phosphorylated on S218 and S222 is active.
MAP2K1 → MAPK1
Active MAP2K1 phosphorylates MAPK1 on Y187.
MAPK1 phosphorylated on T185 and Y187 is active.
MAPK1 → ELK1
Active MAPK1 phosphorylates ELK1 on S383.
ELK1 phosphorylated on S383 and S389 is active.
ELK1 → FOS_family
Active ELK1 in the nucleus increases the amount of FOS_family.
FOS_family → FOS_family
FOS_family is a part of FOS_family bound to JUN_family.
FOS_family → CCND1
FOS_family bound to JUN_family increases the amount of CCND1.
CCND1 → CCND1
CCND1 is a part of CCND1 bound to CDK4.
CDK4 → RB1
CDK4 bound to CCND1 phosphorylates RB1 on S807.